POTS: Postural Orthostatic Tachycardia Syndrome

POTS is the most common autonomic nervous system disorder and an under-recognized health condition that affects teens and adults.

What is POTS?

Postural Orthostatic Tachycardia Syndrome (POTS) is the most common dysautonomia. Dysautonomia is an umbrella term used to describe any disorder of the autonomic nervous system. It’s characterized by symptoms in multiple organ systems and an abnormal increase in heart rate upon standing (30 bpm in adults, 40 bpm in teens). Hence the meaning of the name: 

Postural: relating to posture or position the body 

Orthostatic: relating to or caused by an upright position 

Tachycardia: a heart rate that is too fast or increased heart rate 

Syndrome: a group of signs and symptoms that occur together 

Among many other functions in the body, the autonomic nervous system is responsible for maintaining normal heart rate and blood pressure whether sitting, standing, or lying down. One example of the ANS is working as it should is when a person stands up and the blood vessels in the lower body constrict. This keeps the blood from pooling in the lower extremities and gut and continues consistent blood flow to the vital organs including the heart, lungs, and brain. In a POTS patient, the ANS does not function properly. The blood flow to the brain may decrease and the patient may feel dizzy or light-headed, or they may even faint upon standing. The heart rate increases as the body recognizes this decrease in blood flow.  

Some providers use terms to describe variations in types of POTS: 

Neuropathic POTS: Damage to small fiber nerves that regulate blood vessel constriction in extremities and abdomen 

Hyperadrenergic POTS:  Elevated levels of stress hormone, norepinephrine; overactivity of sympathetic nervous system and may include hypertension (high blood pressure) in some cases 

Hypovolemic POTS: Low blood volume may lead to POTS and symptoms also seen in neuropathic and hyperadrenergic POTS 

Secondary POTS: Associated with co-existing conditions (i.e., autoimmune, Lyme disease, diabetes) 

Signs and Symptoms

With POTS, abnormal symptoms may present in many parts of the body, including abnormal blood flow to the heart, lungs, and brain. It often involves problems with digestion, temperature regulation, and many other involuntary functions of the body. Because the condition involves the autonomic nervous system, which regulates mostly internal functions such as breathing, heart rate, and blood pressure, to name a few. POTS is commonly known as an “invisible illness.” The symptoms often change over time.  

Other possible symptoms:  

  • Lightheadedness, faintness 
  • Syncope (fainting) 
  • Short term memory loss 
  • Mental clouding (brain fog) 
  • Difficulty finding words 
  • Difficulty with depth perception 
  • Sensory integration issues (light and motion) 
  • Paresthesia (tingling, prickly, pins and needles sensation) unilateral/bilateral 
  • Migraine headaches 
  • Fatigue 
  • Exercise intolerance 
  • Heat intolerance 
  • Temperature dysregulation 
  • Abnormal sweat (Anhidrosis = too little; Hyperhidrosis= too much) 
  • Abnormal tears 
  • Abdominal pain 
  • Nausea 
  • Constipation 
  • Diarrhea 
  • Intermittent gastroparesis (partial paralysis of the stomach) 
  • Reflux 
  • Flushing 
  • Circulation issues 
  • Palpitations 
  • Difficulty breathing 
  • Vomiting 
  • Muscle weakness or hypotonic (low muscle tone) 
  • Anxiety or depression 
  • Tinnitus (ringing or other noises in one or both ears) 
  • Weight gain 
  • Panic attacks 

POTS symptoms can change and become worse depending on the environment, situation, or other biological factors.  

  • Standing for long periods of time 
  • Warm environments including hot showers or baths or being in the sun 
  • During menstruation 
  • Pregnancy 
  • Strenuous exercise 
  • Illness (viral or infection) 
  • During or after a stressful situation  

Who does POTS affect?

Mothers Day in Family

POTS develops more often in adolescents and young adults. It affects an estimated 1 in 100 teenagers.  The average age of individuals diagnosed with POTS is between 12 and 50.  It is more common in women than in men with a 5:1 ratio. POTS may run in families. Although a specific genetic association has not been identified, there may be a genetic predisposition for POTS. Often an illness or trauma serves as a trigger for onset. 

POTS may develop after or along with: 

  • Viral or bacterial infection 
  • Pregnancy 
  • Physical trauma including concussions, car accidents, spinal injury among others 
  • Surgery 
  • Autoimmune conditions (notably Sjogren’s syndrome or celiac disease) 

[Note: A long period of bedrest can often cause an abnormal heart rate when standing that mimics POTS. This is a typically a temporary abnormality and should not be confused with a full onset of POTS symptoms.]

Some POTS patients have coexisting conditions. This is not an exhaustive list.  

  • Chronic fatigue 
  • Migraines 
  • Fibromyalgia 
  • Ehlers Danlos Syndrome & Joint Hypermobility 
  • Autoimmune diseases 
  • Functional GI disorders 
  • Mast Cell Activation Syndrome (MCAS) 
Doctor assistant checking list diagnosed of patients

How is POTS Diagnosed?

It can be challenging to diagnosis POTS because the symptoms vary from patient to patient and most providers have not been trained to identify or understand autonomic disorders. Often patients see several doctors over the course of many years without receiving an accurate diagnosis. It’s important to find a provider who understands dysautonomia. That physician should start by conducting a clinical assessment which includes a comprehensive medical history and physical examination. 

The tilt-table test used to be the gold-standard of POTS diagnosis. However, a simple orthostatic vitals test can help providers confirm a suspected dysautonomia diagnosis. 

Orthostatic Vitals Test: This test can be performed in a provider’s office by a nurse or properly trained staff member. The test results may provide meaningful data about the patient’s response to orthostatic stress. More importantly, an orthostatic vitals test may confirm a suspected dysautonomia without the use of expensive diagnostic testing.  

Tilt Table Test: This test is done to see how the body reacts to changes in position without the use of the large muscles in the legs which act as a secondary muscle to increase circulation. A tilt-table test is helpful when a patient presents with POTS symptoms, but their heart rate does not reach a 30 to 40 bpm increase. By eliminating the use of the leg muscles, with a tilt test a provider can determine if the orthostatic stress is causing an abnormal increase in heart rate. 

Prognosis and Treatment

Researchers do not completely understand what causes POTS. While POTS is not life-threatening, it can be very debilitating. There’s no known cure, but symptoms can be managed. There’s no one course for treatment because patients may experience varying symptoms and severity of symptoms. Any treatment should be done while under the care of a provider who understands ANS dysfunction. Some of the non-pharmacological treatments used for common symptoms include:  

  • Increasing water intake to keep your blood volume up. 2-4 liters fluid daily is recommended 
  • Adding sodium (salt) to your daily intake or the use of sodium supplements. Salt helps to retain fluid volume in your blood. 5-9 grams of salt daily is recommended.  
  • Movement and/or exercise daily is recommended. Some patients may benefit from physical therapy, aquatic therapy, cardiac rehab 
  • Diet changes: Eat smaller, more frequent meals to aid in digestion. Large meals worsen dizziness because they shunt up to five times more blood into the abdominal area. This causes a drop in blood pressure also known as postprandial hypotension). Some patients find it helpful to incorporate salty snacks.  
  • Wearing compression garments to avoid excessive pooling of blood in the legs and abdominal area.  


Some of the top pharmacological treatments may include:  

  • Fludrocortisone: Increases blood volume and blood pressure. May help in reducing plasma NE with long-term use. (Orthostatic intolerance and orthostatic hypotension.) Increase dietary sodium for maximum effectiveness. Ideal in low doses. 
  • Midodrine: Tightens blood vessels, increases blood pressure and prevents fainting. (Orthostatic hypotension, POTS and other forms of dysautonomia.) Can cause supine hypertension. 
  • Beta-Blockers: Decrease heart rate, blood pressure and adrenaline effects. Prevents fainting. (POTS and hyperadrenergic hypertension.) Known to cause mast cell degranulation. 
  • Pyridostigmine: Increases blood pressure and muscle strength. Reduces breakdown of Acetylcholine in ANS. (Chronic orthostatic hypotension.) 


Many POTS patients find that a combination of treatments involving medications, diet and lifestyle changes, physical therapy, and even alternative treatments, can help them manage symptoms.  

Living with POTS

Every POTS patient has their own journey. It’s important to take ownership of your own health and advocate for yourself. The number one treatment is education. This means learning a much as you can about POTS and your own body. The goal is to increase your number of good days while decreasing your level of disability.  

As you work with your provider to find treatments that decrease your symptoms, it will take patience and persistence. Understanding what makes your symptoms worse and what makes them better will help you find a new normal for your life. This involves tracking your symptoms and making note of any reactions to medicines, food, and activities, so your provider can better understand how to treat you.  

Family cooking sandwiches together

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2 Responses

  1. My wife is 63 and has many of the POTS symptoms listed here, many of which started appearing after our first COVID vaccination when they first became available. Her symptoms are worsening so last week she had the tilt table test and passed out. The technician conducting the test mentioned that there has been a large increase of women coming in for this test since the start of COVID. Another piece of the puzzle these days?

    1. Yes! We have seen a huge increase in the number of people being diagnosed with an autonomic disorder like POTS since the start of COVID. It makes sense because there is believed to be a link to between infections (viral and bacterial) and the development of POTS. Research in this area is still developing!

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